Thiamine

Question: At what rate does thiamine need replacing in the body of a regular drinker? Just thinking about cutting back my drinking permanently. Been drinking fairly heavily for too many years and the doctors are telling me it's causing me significant vitamin B1 deficiencies. I'm really curious about how quickly alcohol diminishes the body's supplies of thiamine?

Answer: I have read over your question. It's funny because it make me want to ask you a question(s) but of course I can't. May I email you a few things and fact based information that at the very least will give you a better understanding or hopefully empower you with some more knowledge. With your permission first! Medical Specialist MRI/HR/DIR 21 years & still learning!

Question: what is the pka of the proton inbetween the N and S in thiamine? thiamine is used as a catalyst and that proton is removed by a base to activate it. does anyone know what its pka is?

Answer: According to this abstract it seems to have a pKa of 17-19: http://www.ncbi.nlm.nih.gov/pubmed/2844248 Hope that's of help.

Question: Can I feed my bearded dragon Thiamine? I will need to freeze the veggies for him, and I heard it destroys thiamine (Vitamin B1) and beardies have to have it. Can I put some human grade thiamine supplement on his food? Will human grade thiamine be bad for him? (Only Beardie experts please) I want to freeze the veggies so they last longer.

Answer: i own a beardie myself and i never freeze his veggies if possible dont freeze his veggies if i were you i would not put human thiamine in his veggies

Question: Please help...How much ammonium sulfate or thiamine should i add to my apple cider to ferment it into vinegar? amount per quart or gallon please. ammonium sulfate and thiamine are both yeast nutrients...how much of it so i add? sorry typo, how much of it DO i add?

Answer: None at all. Cider does not ferment directly into vinegar, it's a two step process. First you have to ferment it into hard cider by the addition of yeast. Some yeast nutrients may be necessary (diammonium phosphate, ferm-aid, etc.) to get a good, thorough fermentation. Second, the fermented cider needs exposure to air for oxygen and then have acetobacter introduced...you can either hope that it's naturally occurring in the air (not uncommon) or you can introduce it (preferred, for controlled results). Acetobacter is a bacteria that converts the alcohol from the fermented cider into acetic acid in the presence of oxygen. Acetobacter cultures can be found in home brewing supply stores,commonly known as "vinegar mother." Here are some examples: http://ohioline.osu.edu/hyg-fact/5000/5346.html http://www.associatedcontent.com/article/33005/make_homemade_apple_cider_vinegar.html

Question: What is the symbol for the following: Thiamine mononitrate, ferric orthophosphate and ferrous sulfate?

Answer: [1] C12H17N5O4S or (C12H17N4OS)(NO3) [2] FePO4 [3] FeSO4

Question: Is it true that one way to prevent the DENGUE is to take vitamins specifically B1 Thiamine hydrochloride? Some previous studies reveal that intake of high doses of vitamin B1 (25-50 mg 3x a day) may be an effective repellant against mosquito bites. Vitamin B1, or thiamine hydrochloride, in a safe and water soluble vitamin which produces a skin odor that is not detectable by human, but is disagreeable to mosquitoes. Thiamine hydrochloride most likely acts to combine with the perspiration of the host to repel insects by its odor. According to Allan Greene, M.D. FAAP, August 11, 1992; it takes about 2 weeks before the odor of thiamine fully saturates the skin Silva et. al. in 1995 (Re. Hosp Clin, Fac Med, Jao Paulo Vol 50, No1) reports a widely help opinion in Brazil, that vitamin B complex is useful as a mosquito repellant Dengue is now the most important mosquito-borne viral disease in the world affecting young and old, rich and poor .

Answer: You've answered your own question very well

Question: What enzyme would be affected by beriberi or the lack of thiamine?

Answer: Thiamine is one of the B vitamins and plays an important role in energy metabolism and tissue building. It combines with phosphate to form the coenzyme thiamine pyrophosphate (TPP), which is essential in reactions that produce energy from glucose or that convert glucose to fat for storage in the tissues. When there is not enough thiamine in the diet, these basic energy functions are disturbed, leading to problems throughout the body.

Question: Is there any major side effect produced when taking Thiamine and consuming alcoholic beverages? I don't know if this is relevant but it's the adult dosage of Thiamine HCL 300 mg.

Answer: There is no interaction between the two. Actually, a while ago there was consideration to supplementing alcohol with thiamine because alot of alcoholics who dring alot and do not eat get thiamine deficiencies that lead to a swelling of the brain that can be fatal

Question: E. Explain in proper biochemical terms why individuals with a thiamine-deficient diet have relatively high lev? E.Explain in proper biochemical terms why individuals with a thiamine-deficient diet have relatively high levels of pyruvate in their blood.

Answer: http://en.wikipedia.org/wiki/Alanine_transaminase or http://www.vitamins-supplements.org/thiamin-deficiency.php try these

Question: why is thiamine mononitrate used in hersheys cookies and creme candy bars? i really need to know cuz my chem. project is due tomarrow and ive searched everywhere on line and cant find out why!!!! this is superly important!!! please help!! =) also what kind of emulsifier is used in the same candy bars and why??

Answer: Thiamine mononitrate is a form of vitamin B1. It's just a nutritional supplement. Polyglycerol polyricinoleate (PGPR) is an emulsifier used in the making of chocolate. It is made from castor beans and helps reduce the viscosity of chocolate allowing it to flow more easily when melted.

Question: What is 121 Thiamine tablets 100mg used for? my dad who used to have drink problems take these and i want to know what its for???

Answer: GO TO WEB MD SITE , THEY HAVE A PILL LOOK UP SITE THERE AND WILL TELL YOU ALL ABOUT WHAT IT DOSE

Question: Why is thiamine administered with dextrose/saline IV infusion for diabetics?

Answer: The role of thiamine (vit b1) in the body is to act in a co-enzymatic function to help convert carbohydrates and fats in energy production. Without it you could develop beri-beri, Wernicke's Korsikoff Syndrome, lactic acidosis, or in diabetics, there is a rare disorder called TRMA or Thiamine Responsive Megaloblastic Anemia. TRMA is characterized by megaloblastic anemia, sensorineural hearing loss, and diabetes mellitus. Megaloblastic anemia occurs between infancy and adolescence. The anemia is corrected with pharmacologic doses of thiamine (vitamin B1) (25-75 mg/day compared to US RDA of 1.5 mg/day). However, the red cells remain macrocytic. SLC19A2, which encodes the high-affinity thiamine transporter, is the only gene known to be associated with TRMA. High-dose thiamine supplementation may delay onset of diabetes mellitus, and high-dose thiamine invariably improves the hematologic picture. TRMA is aka Rogers syndrome. Fewer than 30 pedigrees are known. TRMA is exceedingly rare outside of consanguineous pairings or isolated populations. Cases have been observed in Israeli Arab and Lebanese populations, an Alaskan kindred of Native and ethnic Russian descent, and kindreds from Brazil, Japan, Oman, Tunisia, Italy (Venetian and other), Iran, and Pakistan, as well as Kashmiri families in Great Britain, ethnic Kurds, Caucasians, and African-Americans. TRMA showed that absence of the high-affinity component of thiamine transport results in low intracellular thiamine concentrations. Defective RNA ribose synthesis caused by intracellular thiamine deficiency is thought to be the cause of megaloblastic changes in TRMA. It is also normal for the administration of Thiamine to patients who are hypothermic for the reason of alcohol abuse. Even if it isn't the case. The MOA here is that thiamine will help reduce potential harmful symptoms that may occur when alcohol is involved. Such as neuropathies. It is unknown what is the role of thiamine in normal hematopoiesis.

Question: What is the association between metabolic acidosis caused by high levels of lactate with thiamine deficiency?

Answer: Thiamine is a coenzyme for pyruvate dehydrogenase and if severely deficient pyruvate will not be metabolised to acetyl CoA and instead glucose metabolism will be forced down the nonoxidative pathway to form lactate.

Question: Abnormal Folate and Thiamine (b1) levels in blood work? Abnormal Folate and Thiamine (b1) levels in blood work? They came back high Folate: 20 (normal is less than 5.38) Thiamine: 79.5 (normal is 25.0-75.0) What could this mean?

Answer: Not quite sure what this has to do with Diabetes. As you are in the Diabetes channel, meant for sharing Diabetes related answers and info. The best bet would be to talk to the Doctor who gave you the blood test/results. There must be a reason they were testing for those specific levels. Cheers and best of health

Question: Diabetes follows a prolonged thiamine deficency. Has your MD to checked your plasma thiamine? Balance thiamine and reverse diabetes. Learn more about the study at AlliesResearch.com.

Answer: I don't think my MD knows what plasma thiamine is, let alone what it does. (kidding, of course). Seriously, I think we need to launch an awareness campaign that will put the women's movement, civil rights movement, and gay awareness to shame with it's notoriety. More pressure on doctors, insurance companies, CDC, major medical universities, congress, and the mass media to get the word out.... Diabetes needs more attention. We outnumber AIDS patients 10 to 1, but who gets all the attention? I mean, really? What's going on, here? Notice I left out the big pharmaceutical companies. We all know what they want.

Question: what is the structrual formula and chemical formula for thiamine mononitrate? need it fast

Answer: structure: http://www.chemicalland21.com/lifescience/foco/532-43-4.gif formula: C12H17N5O4S